Research on acne and food intolerances An intolerance may stem from one or more of the following, though not exclusively:

Seeds (allergenic proteins + protease inhibitors)
- Legumes
  - Common Examples: #1 Peanuts (avoid roasted), Soy
- #3 Tree Nuts
- Grains
  - Common Examples: Wheat, Barley, Rye (all containing gluten protein)
- Cacao Beans https://discord.com/channels/1169738819688468501/1179948804116598804/1208260404103479326
- Sunflower seeds
#2 Shellfish (tropomyosin protein)
Dairy (Whey protein, etc)
- Casein protein intolerances (this may also increase fasting insulin, reduced with fermentation using L. casei / L. paracasei #deleted-channel )
  - A1 beta-casein: may be harder to digest than A2
  - A2 beta-casein
- Whey protein intolerances (this may also increase fasting IGF-1)
- Skim milk (increases intolerance ratio by reducing concentration of fat, and increasing concentration of other components listed here)
- IGF-1 presence (reduced with fermentation, organic/non-rBGH) https://discord.com/channels/1169738819688468501/1250722305261305947
- Lactose sugar (reduced with fermentation)
- Pasteurized, ultra-heat treated (nutrient loss, etc)
- Homogenized fat
- Histamines (particularly in aged cheeses)
- Mould presence (particularly in aged cheeses)
Eggs
- Egg whites (more common allergen than yolk, various proteins could cause it especially if undercooked)
- Egg yolk (higher amounts of progesterone than egg whites)
- Poorly fed chickens
- Cooking preparation method
Nightshades
- Common Examples: Tomatoes, Potatoes, Bell Peppers
Fructans
- Common Examples: Wheat, Onion, Garlic
Salicylates
Additives: food preservative, sweeteners, etc https://discord.com/channels/1169738819688468501/1179949494788431872
Foods high in anti-nutrients

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Chip changed the channel name: Consumption - Food Intolerances (allergens and/or sensitivities) 1/12/2023 12:11 PM

Chocolate consumption may exarcerbate acne

https://discord.com/channels/1169738819688468501/1267363996885979166 (edited)

Food intolerances and acne

Food Allergy as a Risk Factor for Acne: A study published in 2022 in "Voprosy pitaniia" found that food allergies might be a risk factor for acne. The study observed a high frequency of sensitization to food allergens in acne patients, with significant allergens including chicken egg, chicken meat, barley, oat groats, cow's milk protein, and beef. An elimination diet led to a regression of skin inflammatory manifestations in 71.9% of cases, suggesting a possible link between food allergies and acne development [Barilo & Smirnova, 2022]. Diet and Skin Conditions: A 2020 article in "Cutis" discussed the role of diet in various skin conditions, including acne vulgaris. It noted that high glycemic index foods are associated with acne vulgaris. The article also mentioned that children with atopic dermatitis (AD) are at higher risk for food allergies, and a subset may experience flares in relation to non-IgE-mediated food allergies [Greenberg, 2020]. (edited)

Celiac disease

"having a diagnosis of acne was positively associated with celiac disease (OR 1.34, 95 % CI 1.20–1.51)." Lebwohl, B., Sundström, A., Jabri, B., Kupfer, S. S., Green, P. H., & Ludvigsson, J. F. (2014). Isotretinoin use and celiac disease: a population-based cross-sectional study. American journal of clinical dermatology, 15(6), 537–542. https://doi.org/10.1007/s40257-014-0090-8 The odds ratio (OR) for acne associated with celiac disease (CD) found in the paper "Risk of Skin Disorders in Patients with Celiac Disease: A Population-Based Cohort Study" by Benjamin Lebwohl et al., was 1.39 (95% CI 1.29-1.50). Lebwohl, B., Söderling, J., Roelstraete, B., Lebwohl, M., Green, P., & Ludvigsson, J. (2020). Risk of Skin Disorders in Patients with Celiac Disease: A Population-Based Cohort Study.. Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2020.10.079. Positive transglutaminase antibody levels are significantly associated with acne vulgaris. Stewart, T., & Bazergy, C. (2018). Hormonal and dietary factors in acne vulgaris versus controls. Dermato-endocrinology, 10. https://doi.org/10.1080/19381980.2018.1442160. (edited)

IgG and acne

Significantly higher levels of IgG2, IgG3, total summated IgG and total IgG were found in severe acne patients as compared with control subjects. https://sci-hub.se/10.1111/j.1365-2133.1986.tb02826.x IgG-based elimination diets RCTs on other conditions:

W. Atkinson et al. (2004) - 515 citation Key finding: Food elimination diets based on IgG food antibodies may improve irritable bowel syndrome symptoms in patients.
Kadriye Alpay et al. (2010) - 148 citations Key finding: Diet restriction based on IgG antibodies effectively reduces the frequency of migraine attacks in migraineurs.
Viran Gunasekeera et al. (2016) - 52 citations Key finding: An IgG4-guided exclusion diet can improve quality of life and symptoms in patients with Crohn's disease.
Yangzhi Xie et al. (2019) - 26 citations Key finding: A diet based on IgG elimination combined with probiotics may improve migraine symptoms and gut function, potentially reducing medication use.
L. Jian et al. (2018) - 20 citations Key finding: An IgG-guided exclusion diet improved symptoms and quality of life in patients with ulcerative colitis.
R. Neuendorf et al. (2019) - 4 citations Key finding: A targeted elimination diet based on IgG testing can improve sleep quality in overweight/obese adults, but not overall health.
L. Ostrowska et al. (2021) - 4 citations Key finding: IgG-based elimination-rotation diets show significantly better results in treating mixed irritable bowel syndrome symptoms compared to FODMAP and control diets.
A. Vink et al. (2014) - 1 citation Key finding: An individual diet based on IgG ELISA in dogs significantly improves atopic dermatitis, pruritus, and other non-specific allergic skin reactions.
Yang Chong-mei et al. (2011) - 0 citations Key finding: Eliminating IgG-positive food from ulcerative colitis patients' diets can improve therapeutic efficacy and may be related to the incidence of the disease.

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1:09 PM

From "Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study." Total patients in the study, which was 97 Food Items | Total Patients | Grade + | Grade ++ | Grade +++ | Positive Rate, % -----------|----------------|---------|----------|-----------|------------------ Egg | 58 | 4 | 6 | 48 | 59.79 Wheat | 37 | 14 | 7 | 16 | 38.14 Milk | 31 | 7 | 9 | 15 | 31.96 Corn | 29 | 15 | 6 | 8 | 29.9 Tomato | 25 | 10 | 5 | 10 | 25.77 Crab | 22 | 19 | 3 | 0 | 22.68 Rice | 17 | 2 | 6 | 9 | 16.49 Soybean | 16 | 4 | 1 | 11 | 15.46 Cod | 9 | 2 | 2 | 5 | 9.28 Shrimp | 3 | 1 | 0 | 2 | 3.09 Mushroom | 2 | 1 | 1 | 0 | 2.06 Beef | 2 | 0 | 2 | 0 | 2.06 Chicken | 0 | 0 | 0 | 0 | 0 Pork | 0 | 0 | 0 | 0 | 0 (edited)

From "Impact of Food Immunoglobulin G-Based Elimination Diet on Subsequent Food Immunoglobulin G and Quality of Life in Overweight/Obese Adults" for more data: https://sci-hub.se/10.1089/acm.2018.0310 https://sci-hub.se/10.1136/gut.2003.037697 https://sci-hub.se/10.1155/2019/7890461 https://sci-hub.se/10.1177/0333102410361404 https://sci-hub.se/10.1007/s10620-015-3987-z (IgG4 rather than IgG) (edited)

http://www.aimspress.com/article/doi/10.3934/Allergy.2023010 (edited)